Protein Interaction Network
What is Protein Interaction Network?
With in a cell, proteins work with other proteins to achieve their functions. Proteins can be in physical contact with specific proteins to work together. This is called the protein interaction network. This relationship is usually modeled in graphs with nodes as genes and relation as edges. [1]
How to learn about Protein Interaction Network?
DYX1C1 protein network were obtained from STRING Database. STRING is a database of protein protein interactions including known and predicted. GO terms and clustering were studied from this Database.
How does the Protein Interaction Network of DYX1C1 looks like?
DYX1C1 along with DCDC2 and KIAA0319 are know to be genes associated with Dyslexia. It is not a surprise to find them in DYX1C1's protein interaction network. According to the interaction network, among the 3, DYX1C1 is related to axonemal dynein complex assembly.
Another interesting finding in the human interaction network is the gene GCFC2, which is a factor that repress transcription by binding to GC rich regions in beta-actin, and involves in pre-mRNA splicing. [2] GCFC2 has low specificity to body regions, which is similar to DYX1C1. [3] I thus looked further in alternative splicing relating gene in the net work.
human - blue color
Select with UniProt Keyword: Alternative Splicing
Select with UniProt Keyword: Alternative Splicing
This suggests that neuronal migration and cilium assembly might have underlying molecular explanations related to alternative splicing. Interestingly, I wasn't able to find GCFC2 in the close interaction network of DYX1C1 in mouse.